Current Issue : July-September Volume : 2013 Issue Number : 3 Articles : 3 Articles
The present investigation was aimed at investigating the potential of Pistacia Vera Linn. outer seed shell powder (PV-SSP) as superdisintegrant while formulating orodisperse exhibiting lowest disintegration time with enough mechanical strength. Interaction of piroxicam (PX) and β-cyclodextrin (β-CD) was investigated in solid state. Solubility studies demonstrated that the formation of PX- β-CD inclusion complex with 1:1 stoichiometry. Orodisperse prepared with PV-SSP (10% w/w) were directly compressible and showed superior disintegrating property due to decreased water sorption time, wetting time, increased water absorption ratio, without any significant change in swelling index. The mechanism of superdisintegration suggested that when PV-SSP used in formulation and compressed into tablet it get deformed and after contact in water these deformed particles get into their normal structure and produces a break-up of the tablet. The in-vitro release results displayed that orodispersible tablet containing PX- β-CD solid complex displayed faster PX release compared to those containing free drug. Thus, the findings signalled great potential for using PV-SSP as superdisintegrant in orodisperse with low disintegration time....
The naturally occurring polysaccharides are currently getting prime importance in pharmaceutical dosage forms because of their easy availability, non-toxic, eco-friendly and biodegradable nature. The Guar gum, which is obtained from Cyamopsis tetragonolobus Linn. (Family: Leguminosae) is rich in gallactomannan having unique gelling or thickening properties. The presence of multiple hydroxyl groups in gallactomannan has proved to be excellent for derivatization by grafting or cross-linking with other polymers to create new chemically modified entity of desired properties. The native as well as guar gum derivatives are found to have therapeutic importance in crohn''s disease, colitis, irritable bowel syndrome, hypercholesterolemia and colorectal cancer. Guar gum is used as suspending, emulsifying, binding, disintegrating and stabilizing agent in the conventional pharmaceutical dosage forms. The swelling property of guar gum has made it suitable for controlling the drug release rate in the novel pharmaceutical dosage forms. By virtue of its better thickening and stabilizing power accompanied by a sound safety profile, guar gum has acquired a wide acceptance in cosmetics and food industry. The present review discusses the excipient profile of guar gum, its present status and application based on available literatures....
Mucilages and gums are most commonly used excipients in pharmaceutical preparations and can be derived from plants and plant parts. The present study aimed at isolation and characterization of mucilage from jackfruit. The mucilage was isolated from the jackfruit pulp by the aqueous extraction method and characterized for various physiochemical parameters such as solubility, pH, loss on drying, swelling index, test for carbohydrates, test for tannins, test for chloride, test for sulfate, viscosity, total carbohydrates content, and sugar analysis using thin layer chromatography. The mucilage was further characterized for flow properties as well as for its adhesive properties. The yield of mucilage was 15 % w/w. The isolated mucilage showed good physicochemical characteristics, flow properties and adhesion characteristics. Thus, from the studies, it is concluded that jackfruit mucilage can be used as mucoadhesive component in pharmaceutical formulations due to its adhesive characteristics....
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